Du Mez—The Galenical Oleoresins. 
1043 
1910 
Oleoresina Cubebae 
Oleoresin of Cubeb 
Oleores. Cubeb 
Cubeb/ in No. 30 powder/ five hun- alcohol to evaporate, in a warm place, 
dred grammes .500 Gm. stirring frequently. 7 Keep the oleo- 
Alcohol/ a sufficient quantity. resin in a well stoppered bottle. 9 
Place the cubeb in a cylindrical NOTE-—Oleoresin of Cubeb, after 
glass percolator/ pack the powder standing for some time, deposits a 
firmly, and percolate slowly wfith alco- waxy and crystalline precipitate, 
hoi, added in successive portions, until which should be rejected, the, liquid, 
the drug is exhausted. 5 Eecover the portion only being used. 8 
greater part of the alcohol from the Preparation—Trochisci Cubebae. 
percolate by distillation on a water- Average Dose—Metric, 0.5 Gm.— 
bath, 6 and, having transferred the Apothecaries, 8 grains, 
residue to a dish, allow the remaining 
1) For a description of the drug, see page 1040 under ‘'Drug 
used, its collection, preservation, etc.” 
2) The last three editions of the Pharmacopoeia have specified 
that the drug used be reduced to a No. 30 powder for perco¬ 
lation. Previous editions, with the exception of that of 1850, 
directed that a fine powder (No. 60) be used for this purpose. 
In the Pharmacopoeia of 1850, the degree of fineness was not 
specified. The coarser powder corresponds more nearly in its 
composition to that of the whole fruit than does the fine pow¬ 
der, owing to the fact that a relatively large amount of vola¬ 
tile oil is lost in the preparation of the latter. 
3) Previous to the edition of 1900, the Pharmacopoeia speci¬ 
fied the use of ether for extracting the drug, whereas, the last 
two editions have directed that alcohol be employed for this 
purpose. The fact, that the latter yields a product differing 
but slightly in its physical properties from the oleoresin ob¬ 
tained with ether, was pointed out by Procter in 1866, and 
later confirmed by other investigators. Since the alcoholic 
preparation appears to be equally as efficient from a therapeu¬ 
tic standpoint, as well, the change from ether to alcohol ap¬ 
pears to be justified. The use of a menstruum consisting of 
equal parts of alcohol and ether, as specified in some of the 
foreign pharmacopoeias, the Austrian, German and Japanese, 
