1058 Wisconsin Academy of Sciences , Arts, and Letters. 
her, 26.7, obtained in the ease of the preparation made with 
alcohol agrees very well with that (26.2) obtained by Kremel 
for the oleoresin when prepared in a like manner. The low acid 
numbers obtained for the commercial samples are explained 
by the presence of relatively large amounts of volatile matter 
(generally essential oil, but unevaporated solvent in two cases) 
in these preparations, which has the effect of reducing the con¬ 
centration of the free acids. The values obtained for this 
constant follow: 
Table 57.— Acid numbers of laboratory preparations. 
Sample 
No. 
Date 
Observer 
Solvent 
Acid number 
t 
1887 
Kremel.................... 
Alcohol.................... 
26.2 
2. 
Ether ............ ......... 
31.2 
1___ 
1916 
DiiMfiz .. .... 
Alcohol........... 
26.7 
2.... 
Acetone ................... 
22.8 
8 ......... 
“ 
Ether .... 
22.2 
4......... 
“ 
4 
Petrol, ether .... 
21.8 
Table 58 ..— Acid numbers of commercial oleorcsins. 
Sample 
No. 
Date 
Observer 
Source 
Acid number 
1 
1916 
DiiMps . 
Lilly & Co.................. 
12.8 0) 
13.4(i) 
14.4 
15.4 
18.7 
2 
Squibb & Sons ............ 
SL 
“ 
Stearns & Co .............. 
4 
64 
Parke, Davis & Go. 
5. 
Sharp & Dohme.. . 
0) Probably contained unevaporated solvent (alcohol). 
Saponification value; The saponification values obtained for 
the oleoresins prepared in the laboratory showed a slight 
variation due to the nature of the solvent used in extracting 
the drug as is shown in the first of the tables which follow. As 
a rule, however, the difference in the volatile oil content of the 
oleoresin, due to a variation in the conditions under which it 
has been prepared, is thought to be the principal factor in¬ 
fluencing the value of this constant, as is also brought out in the 
first table. In the examination of commercial samples, the 
presence of unevaporated solvent must be taken into considera- 
