1090 Wisconsin Academy of Sciences, Arts, and Letters. 
1890 
Oleoresina Lupulini 
Oleoresin of Lupulin 
Lupulin/ one hundred grammes . the drug is exhausted.* Recover the 
.... 100 Gm. greater part of the ether from the 
Ether/ a sufficient quantity. percolate by distillation on a water - 
Put the lupulin into a cylindrical bath/ and, having transferred the 
glass percolator, provided with a residue to a capsule, allow the re¬ 
stop-cock, and arranged with a cover maining ether to evaporate spontan- 
and receptacle suitable for volatile eously.® 
liquids. 3 Press the drug very lightly, Keep the product in a well-stop- 
and percolate slowly with ether, pered bottle/ 
added in successive portions, until 
1900 
Oleoresina Lupulini 
Oleoresin of Lupulin 
Lupulin/ five hundred grammes...... Recover the greater part of the ace- 
.... 500 Gm. tone from the percolate by distilla- 
Aeetone/ a sufficient quantity. tion on a water-bath/ and, having 
Introduce the lupulin into a cylin- transferred the residue to a dish, al- 
drical glass percolator, provided with low the remaining acetone to evap- 
a stop-cock, and arranged with a orate spontaneously in a warm place.® 
cover and a receptacle suitable for Keep the oleoresin in a well-stoppered 
volatile liquids. 3 Press the powder bottle. 7 
very lightly, and percolate slowly Average dose.—0.200 = Gm. 200 
with acetone, added in successive por- milligrammes (3 grains), 
tions, until the lupulin is exhausted. 4 
1) For description of the drug, see page 1088 under “Drug 
used, its collection, preservation, etc.” 
2) The solvents which have been used for the purpose of ex¬ 
tracting lupulin are ether, acetone and alcohol. Of these, the 
first two have been recognized at different times by the 
Pharmacopoeia, acetone being the solvent which was directed 
to be used by the edition of 1900, whereas ether was specified 
in previous editions. 
With respect to the relative values of the above, from a 
therapeutical standpoint, a statement cannot be made owing 
to the lack of specific information on the subject. From a 
pharmaceutical standpoint, however, ether and acetone, re- 
