1096 Wisconsin Academy of Sciences, Arts, and Letters. 
alkaloid possessing a coniine-like odor. Griessmayer, 10 who 
first noted its presence, gave it the name ‘ ‘ lupuline. ’ ’ 
In 1885, Williamson 20 reported the isolation of a crystalline 
alkaloid from wild American hops. He gave it the name 
“hopeine,” and assigned to it the formula, C 18 H 20 NO 4 . H 2 0. 
Ladenburg, 21 who examined a sample of the material thought 
it to be a mixture of morphine and a more soluble base. 22 As 
further work 23 along this line has failed to confirm the findings 
of Williamson, the presence of a crystalline alkaloid must be 
considered doubtful. 
Ash. Analyses of the ash of lupulin have apparently not 
been reported to date. However, Wehmer * 1 states that Ca, Cl 
and Si0 2 are present in the ash from all parts of the hop plant, 
and, as Na, Mg, Fe, Al, and H 3 P0 4 were identified in the ash 
of the oleoresins examined in the laboratory, it is quite probable 
that the constituents of lupulin ash are identical with those 
present in the ash of hops. 2 
There is a great variation in the quantity of ash obtained 
from commercial samples of lupulin owing to contamination 
with sand and other earthy matter. Barth 3 gives the yield of 
ash as 9.5 to 24.4 per cent, while Flueckiger 4 states that a good 
sample of lupulin should give about 7.0 per cent. Accord¬ 
ing to Keller, 5 lupulin, washed free from all earthy matter, 
yielded only 2.37 per cent, of ash. 
Constituents of Therapeutic Importance. 
There appears to be considerable doubt at the present time 
as to the value of the oleoresin of lupulin as a therapeutic 
agent. The presence of the soluble bitter principles is said to 
10 Dingler’s Polytech. Journ. (1874), 212, p. 67. See also Power, Tutin and 
Rogerson, l. c. 
30 Pharm. Ztg. (1885), 30 p. 620. 
21 Ber. der deutsch. Chem. Ges. (1886), 19, p. 783. 
22 Williamson, in a second publication, agrees with the findings of Laden- 
burg and assigns the name hopeine to the more soluble base. Chem. Zeit. 
(1886), 10, p. 491. 
23 Greshoff could not obtain a crystalline alkaloid from lupulin. Dingler’s 
Polytech. Journ. (1887), 266, p. 316. 
1 Wehmer, Die Pflanzenstoffe. Jena (1911), p. 160. 
3 Richardson, in an examination of hop ash, identified the elements, Na, K, 
Ca, Mg. Al and Fe, and the acids, H 3 PG 4 , H 2 CG 3 and H 2 SiO a . Wochenschr. 
Brau. (1898), 15, p. 160. 
3 Zeitschr. ges. Brauw. (1900), 23, p. 509. 
4 Flueckiger, Pharmakopnosie des Pflanzenreiches. Berlin (1891), p. 257. 
6 Pharm. Ztg. (1889), 34, p. 533. 
