1120 Wisconsin Academy of Sciences , Arts, and Letters. 
1900 
Oleoresina Piperis 
Oleoresin of Pepper 
Pepper, 1 in No. 40 powder, 2 five hun¬ 
dred grammes .500. Om. 
Acetone, 3 a sufficient quantity. 
Introduce the pepper into a cylin¬ 
drical glass percolator, provided with 
a stop-cock, and arranged with a cover 
and a receptacle for volatile liquids. 4 
Pack the powder firmly, and percolate 
slowly with acetone, added in succes¬ 
sive portions, until the pepper is ex¬ 
hausted. 5 Recover the greater part 
of the acetone from the percolate by 
distillation on a water-bath, 6 and, 
having transferred the residue to a 
dish, set this aside in a warm place, 
until the remaining acetone has evap¬ 
orated, 7 and the deposition of crystals 
of piperin has ceased. Lastly, sepa¬ 
rate the oleoresin from the piperin by 
straining through purified cotton.® 
Keep the oleoresin in a well-stoppered 
bottle. 9 
Average dose.—0.030 Gm. — 30 mil¬ 
ligrammes (*4 grain). 
1910 
Oleoresina Piperis 
Oleoresin of Pepper 
Oleores. 
Pepper, 1 in No. 40 powder, 2 five hun¬ 
dred grammes .500. Gm. 
Ether, 3 a sufficient quantity. 
Place the pepper in a cylindrical 
glass percolator, provided with a stop¬ 
cock, and arranged with a cover and 
a receptacle for volatile liquids. 4 
Pack the powder firmly, and perco¬ 
late slowly with ether, added in suc¬ 
cessive portions until the drug is ex¬ 
hausted. 6 Recover the greater part of 
the ether from the percolate by dis- 
Piper. 
tillation on a water-bath, 6 and, hav¬ 
ing transferred the residue to a dish, 
set this aside in a warm place until 
the remaining ether has evaporated, 7 
and the deposition of piperine has 
ceased. Lastly, separate the oleo¬ 
resin from the piperine by straining 
through purified cotton. 8 Keep the 
oleoresin in a well-stopped bottle. 9 
Average Dose.—Metric, 0.03 Gm.— 
Apothecaries, % grain. 
1) For a description of the official drug, see page 1117 under 
“Drug used, its collection, preservation, etc.” 
2) The last two editions of the Pharmacopoeia have specified 
that the drug be in the form of a No. 40 powder for percolation. 
Previous editions, with the exception of that of 1850, in which 
the degree of fineness was not stated, required that a fine 
