Du Mez—TJte Galenical Oleoresins . 1133 
finished product, e. g. the piperine content of the preparation 
made with acetone was found to be 54.36 per cent and the 
saponification value 88.6, while the oleoresin when prepared with 
petroleum ether, contained only 15.06 per cent, of piperine and 
gave a saponification value of 109.5. Other influences, besides 
the nature of the solvent, affecting the piperine content may 
likewise produce a variation in the saponification value, e. g. 
the temperature at which the preparation is made and the 
presence of unevaporated solvent in the finished product. The 
latter may also have a direct influence. The saponification 
values as found for the oleoresins examined in the laboratory 
are given in the following tables. 
Table 135— Saponification values of oleoresins prepared in the 
laboratory. 
Sample 
No. 
Date 
Observer 
Solvent 
Saponifica¬ 
tion value 
1 
1916 
DuMez..................... 
Alcohol.................... 
63 7 
2 .. . 
Acetone.... 
74 9 
• • 
Ether.............. ....... 
83 5 
4 
6 4 
»■ 
Petrol, ether............... 
86.8 
Table 136— Saponification values of commercial oleoresins. 
Sample 
No. 
Date 
Observer 
Source 
Saponifica¬ 
tion value 
1 ..... 
1 
j 1916 
DuMez..................... 
Sharp & Dohme........... 
66.3 
73.7(a) 
2 ... 
Squibb & Sons........ .... 
(a) Contained ether. 
Iodine value: Iodine values ranging from 88.6 to 95.4 were 
obtained for this oleoresin when acetone, alcohol or ether were 
the solvents employed in its preparation. This variation is 
due to the difference in the piperine content of these oleo¬ 
resins as a result of operating under different conditions of 
temperature when preparing the same, as well as to the nature 
of the solvent. Jn addition to these influences, the presence 
of unevaporated solvent must also be taken into consideration 
in the case of the commercial samples, as is indicated by the 
values given in the following tables. 
