July, 1923] SANDS — STRUCTURE OF CHROMOSOMES 353 
whose surface are disposed fine granules separated at regular intervals. 
By treatment with the EH method, these granules acquire the deep black 
coloration of the earlier stages while the ground substance appears yet 
paler. According to him, the granules may be looked upon as chromomeres. 
On page 21 of the same paper he says that the constricted chromosomes , 
as they are figured by most authors, especially by Van Beneden, Herla, 
and Bonnevie, consist of independent knots or rings of chromatic substance 
in the ground material which corresponds to the original Lininsubstanz. 
The chromosomes appear here as if segmented, and the individual seg- 
Fig. 5. Chromomeres figured in the metaphases by Flemming (1882). Salamandra. 
Fig. 6. Chromomeres in the prophases, figured by Hermann (1891). Fig. 7. Meta¬ 
phase chromosomes of Salamandra showing granular composition, and assumed by Flem¬ 
ming (1882) to be longitudinally divided. Fig. 8. End views of chromosomes which 
show hollow and quadripartite structure. Merriman (1904). 
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