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Insects and Disease 
of the three well-known types of malarial fever, namely, quartan, tertian,, 
and remittent. And soon after 1885, Golgi and other investigators, Italian, 
English, and American (Celli, Grassi, Mannaberg, Bignami, Danielewsky, 
Carter, Osier, Labbe, Koch, Manson, Councilman, Thayer, MacCallum, 
and others), succeeded in working out in minute detail the behavior, develop¬ 
ment, and. pathological effects, direct and indirect, of the parasites in the 
human blood. From these researches I may summarize the life of the malaria- 
producing Haemamoebae in the human body as follows: The youngest para¬ 
sites, or amcebulae, are found living within the red blood-corpuscles; here 
they grow at the expense of the corpuscle substance. They increase rapidly 
in size, while the blood-corpuscle begins to degenerate. From the break¬ 
ing down of the haemoglobin of the corpuscle, due to the metabolism of the 
parasite, granules of a blackish pigment are formed; this is the melanin 
long known as a regular diagnostic characteristic of malaria. After a few 
days, from one to several depending on the variety of the Haemamoeba, the 
amoebulae reach maturity. They begin now to sporulate; that is, the nucleus 
and cytoplasm divide into many small parts, each nuclear part having aggre¬ 
gated about it part of the cytoplasm. The walls of the blood-corpuscle then 
break, and these many Haemamoeba spores are released into the blood-plasma. 
Each of these spores soon attaches itself to a fresh blood-corpuscle, pene¬ 
trates it, and begins a new life-cycle. It is obvious that such a parasitic life 
