i6 
Bulletin 113. 
of the poison upon the heart and circulation. Most of them were 
disappointing in the extreme. Stimulants are indicated (alcohol* 
camphor, ammonia, strychnine, etc.,), and all are more or less 
beneficial. Glonoin (nitro-glycerine) injected hypodermically, re¬ 
vived the heart’s action and abated the alarming symptoms for a 
time. This, however, did not appear to be a true physiological 
antidote. 
Atropine, given in one half to one grain doses, hypodermically, 
gave satisfactory, and in some cases, astonishing results. Every 
stockman should keep on the ranch a hypodermic syringe for in¬ 
oculating his calves against blackleg, and in this way become 
familiar with the use of the instrument. The atropine tablets can 
be secured at any drug store. A small vial of boiled water may 
be carried in the vest pocket and the remedy quickly prepared and 
given to a number of poisoned animals. The dose is one-half to one 
grain for cattle and horses and one-twentieth of a grain for sheep. 
I have no hesitancy in strongly recommending potassium perman¬ 
ganate, when used in the way indicated, as a chemical antidote, 
and the atropine as a physiological antidote. Either drug may be 
repeated, if necessary, in half an hour. In case these remedies 
are not at hand, any one of the following stimulants might be 
tried: Whiskey, in two-ounce doses, for cattle or horses; aromatic 
spirits of ammonia, two ounces well diluted with water, for cattle 
and horses. Spirits of camphor, one ounce. Fluid extract of bel¬ 
ladonna, two drachms. Nitrous ether, two ounces. For sheep, 
give one-fourth the amount. 
Results of Experiments. In accordance with an agreement 
entered into with the Department of Agriculture, whereby we were 
to conduct a co-operative investigation of loco, larkspur, and other 
poisonous plants, larkspur was gathered at intervals throughout 
the spring months. The first was gathered on April 26th, when 
it was about four inches high, and the last on June 12th, at which 
time the flower was in full bloom and the plants were beginning to 
dry up. It was dug with roots attached and after drying ten days, 
was sent in five pound packages to the Bureau of Plant Industry, 
U. S. Department of Agriculture. 
On October 10th Doctor Crawford reported as follows: 
“The method used in testing the physiological activity of plants was 
to weigh accurately five grams of the powdered plants, then extract this 
over night with twenty c. c. of water, and ten c. c. alcohol added mainly as 
a preservative. The following day the extraction with water and squeezing 
was continued until the fluid became colorless. The fluid was then evaporated 
to dryness in vacuo about 40° C., and the residue made up to 30 c. c. with 
water. Any number of c. c. would do as well. The alcohol was given off 
in vacuo. 
