544 
ORIGINAL ARTICLES. 
Lectures on Experimental Physiology (1854-5, p. 250) he has drawn 
attention to the existence of a sort of animal fecula in the muscles 
and lung of the foetus : but at this time he did not isolate it so as to 
investigate its properties. At a later period he communicated an 
elaborate memoir on the subject “ of the glycogenic matter (amyloid 
substance), considered as a condition of development of certain tissues 
of the foetus before the appearance of the glycogenic function of the 
liver,” to the Academy of Sciences. This memoir was read on the 
4th of April, 1859. In a note likewise, appended to the termination 
of his memoir, “ upon a new function of the placenta,” in the 2nd 
volume of the “ Journal de la Physiologie, &c.” page 39, he speaks 
on the same subject. “ In the foetus,” he says, “ there exists glyco- 
“ genic cells in the various epitheliums of the digestive and respiratory 
“ passages as well as in the skin and its appendages. The presence 
“ of glycogenic cellules may be very well observed, for example, in 
“ the soft horny structure of the hoof of the foetus of the cow, and 
“ this matter may be seen to disappear in the parts which are the 
“ seat of more advanced organisation. These obervations would lead 
ic one to think that in these instances the glycogenic matter is not 
“ changed into sugar, but that it seems to enter directly into the 
“ constitution of the tissues becoming organized along with it; and 
“ one may, I think, extend this idea and apply it to the development 
“ of the other tissues of the foetus which contain glycogenic cells, 
“ as well as to the phenomena of nutrition in the adult with reference 
“ to the part played by the glycogenic matter of the liver, &c. &c.” 
It must be remembered, however, by those who are anxious to 
establish with precision and truthfulness the history of this question, 
that the first researches of M. Charles Rouget, as to the existence of 
Zoamyline in the epithelial cells of the skin and mucous membrane 
were made prior to the note just quoted, and that the facts and ideas 
which this able physiologist has since developed in his articles “ on 
the amyloid substances in the tissues of animals,” in the second 
volume of the Journal de la Physiologique were set forth at several 
meetings of the Societe de Biologie, especially its meeting on the 
5th of March, 1859. 
Although Prof. Claude Bernard has by his discovery of the amy¬ 
loid substance of the liver, and by the addition of many interesting 
and important facts to our knowledge of this substance, done much 
for science, yet it would appear that M. Charles Rouget was in truth 
the first to give to these facts their true signification. It was he who 
announced that the presence of amyloid substance as a constituent 
part of the elements of normal tissues was not limited to a single 
order of animals, or to a single organ (the liver), but that these 
starch-like materials are common to the elements of many organs, 
sometimes only during certain periods of their development, some¬ 
times during life, and that they play an important part in the defi¬ 
nite constitution of the tissues of a great number of the invertebrata. 
He showed that in the larva of the batrachians, zoamyline , as he 
