82 
PHYSIOLOGICAL PATHOLOGY. 
In relation to the blood of rabid animals, we succeeded in one 
instance in giving rabies to a dog with the blood of a rabbit 
which had died mad. We shall return to the consideration of 
this fact, which is one to which great importance attaches. One 
question has occupied us. The fact is generally known that, 
usually, the bitten dog, if he becomes mad, exhibits rage, with a 
desire to bite, and has that special barking known as the rabid 
bark. In the ordinary condition of our experiments, when we 
inoculate the rabid virus into a vein, or into the subcutaneous cel¬ 
lular tissue, it is the paralytic form, without rage or barking, 
which commonly follows. Trephining on the contrary, gives rise 
to furious rabies. We have observed, also, that it was possible to 
obtain furious rabies by the mtra-venous, or hypodermic inocu¬ 
lation, the only condition necessary being that we shall use very 
small portions of virus. The smaller the amount that is used in 
hypodermic or intra-venous inoculation, the more readily the 
furious variety of rabies is produced. We have also observed 
that the use of small quantities in the inoculation may greatly ex¬ 
tend the incubations, and that in carrying the dilution beyond a 
certain limit, not very high, the inoculation remains without ef¬ 
fect. The interest attaching to these conclusions justifies me in 
reporting the details of two experiments. 
On the 6th of May, 1883, three dogs were inoculated in the 
vein of the right hind leg, with rabid virus in a sterilized bouil¬ 
lon. The first dog had \ cubic centimeter; the second, 1-100 ; 
the third, 1-200. 
On the tenth day the first dog had lost his ordinary appetite ; 
on the eighteenth, was entirely paralyzed, and died two days later, 
without bark or rage. The second dog continued to eat on the 
thirty-seventh day after inoculation; the day following he pre¬ 
sented suspicious appearances ; on the next, or thirty ninth day, he 
had the rabid voice, and died on the following day. The third 
dog did not become mad. 
In another experiment, inoculation was performed on a first 
dog, of one cubic centimeter of rabid matter, in sterilized bouil¬ 
lon ; a second received 1-20; and a third, 1-50 of the same mat¬ 
ter. 
