212 
G. SEE. 
also, which become loaded with bacilli; the parasites gathering 
in the glomerutse, even when the renal structure is still quite in¬ 
tact. It is to be observed that the subjects of these experiments 
have been rabbits, which constitute the ground of culture most 
favorable to the bacilli, the tubercule always progressing and de¬ 
veloping favorably and well in this animal. It is not the same 
with the dog, which is hut slightly subject to tuberculosis and so 
effectually resists the experimental treatment that the inoculated 
tuberculosis is generally of a character only, and refuses to extend 
further. (Friedlander.) 
Inoculated Bacilli. —When the tubercle remain of an im¬ 
perfect and neutral character, and lacking in actual virulency, it 
becomes necessary to submit the bacillus itself to the direct ex¬ 
periment of inoculation. For this purpose Koch has employed 
every practicable precaution in order to perfect his experiments 
and remove them from all reasonable doubt or question. 
Implantation of Bacilli into the Eye, the Peritoneum and the 
Blood. —Bacilli have been cultivated upon the coagulated serum 
of the blood; these gathered upon platinum wires passed to 
the fire, in such a manner that the liquid of culture was freed 
from all trace of blood, and of all other microphytes, and was 
composed exclusively of bacilli. These were obtained either 
from the tuberculous matter of man, viz., from human lungs 
affected with granulations or caseous pneumonia, or from the lung 
of monkeys, the inoculation being made by the mode of injection 
iuto the anterior chamber, through the cornea. In all these cases, 
irrespective of what animal had \>een operated upon, the same 
phenomena as those of the inoculation of tuberculous substance 
were observed. With a liquid poor in bacillus, a nodule was 
slowly developed which gradually involved the lymphatie glands, 
which became caseous ; from thence the morbid process extends 
through the blood to the other organs. Or, again, when the 
liquid of culture was rich in bacilli, the tissue in which it had 
been implanted, together with the lymphatic system, become 
rapidly affected, and numerous nodules appear in the lungs, the 
spleen and elsewhere, as if the bacilli had been injected in the 
blood. May not these differences in the development of the 
