PHYSIOLOGICAL PATHOLOGY. 
271 
Blind staggers, I have learned from several gentlemen, has 
been very fatal in the counties near Charleston. This, 1 think, is 
due to turning the horses out all night and their grazing on the 
dewy grass early in the morning. [ have not seen or heard of 
any contagious diseases in cattle. 
A friend of mine on an island adjacent to Charleston has re¬ 
ported a great many of his cows dying from parturient apoplexy. 
Some, he says, have apparently been well in the morning and 
dead at night. The usual remedies have not time to act. He 
says he has not been turning them out at night, but been feeding 
them in stalls. I think he has had them too fat. 
.Respectfully submitted, 
Benj. McInnes, Jr., V.S. 
PHYSIOLOGICAL PATHOLOGY. 
UPON CYSTITIS AND NEPHRITIS PRODUCED IN A HEALTHY 
ANIMAL BY THE INTRODUCTION OP THE MICROCCOCUS 
URINiE INTO THE URETHRA. 
By Messrs. Lepine and G. Roux. 
Half a drop of pure culture of microccocus urince was, by 
means of a flambed pipette, injected into the urethra of a guinea 
pig, and a ligature applied and left on the prepuce for several 
hours. In a few days the region became more or less swollen, 
some slight sloughing occurred, and the urine, which had become 
very aminoniacal, was found to contain many micrococci and 
granular casts. On post-mortem the bladder was found thickened, 
and its mucous membrane reddened, and if the animal had been 
killed, the kidneys were in a congested state, but, if he had been 
allowed to die, (death taking place in a few days,) these organs 
had become yellow. 
In both cases, the examination of well-colored sections has 
shown micrococci in the epithelial cells; and a piece cut from the 
centre of the kidney, carefully obtained, and placed in sterilized 
urine, had given a pure culture of micrococcus in urinse. 
Several healthy (saines) females that were kept in the cage with 
the inoculated males, had also aramoniacal urine, containing 
