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INNOCENTE N080TTI. 
region of the dewlap and its development in its ordinary place of 
selection would be prevented. At first these results were ob¬ 
tained, hut a few failures brought on a discussion between the 
members of the commission and Dr. Nosotti, and it is for this 
reason that the author published the report as merely the result 
of a few experiments made by him; definitive results have not 
yet been reached. 
In order to prosecute his investigations successfully, Dr. No- 
sotti took all the precautions possible, providing himself with the 
best instruments and familiarizing himself with all that has been 
written on the subject of micro-organism. He first learned 
that the existence of the microbe of epizootic aplita had been 
discovered long ago, thus: Haindinger claimed that he had 
found in all the vesicles a kind of fungi which was the original of 
the fungi of rusty plants; Betti claims that this is the oidium 
albicans or mucor albicanus of the muguet of children or young 
calves; Bender found in the envelop of aphta small fungi, very 
small spores, and also numerous microbs ; Bollinger found in these 
vesicles bacteridies and bacilli ; and Rivolta, more careful than 
the others, says that the aphtous virus is composed of round 
microbs of very small size, the largest having a kind of central 
nucleus. All these observers, as Nosotti remarks, had examined 
impure vesicles, that is one mixed with detritus of all kinds, which 
soil the mouth, the udders or the interdigital space, and conse¬ 
quently the number of parasites which they found was not to be 
counted; consequently their researches could not be correct. 
By avoiding their errors, Dr. H. obtained the virus from re¬ 
cently formed vesicles, and took it with a syringe of Pravaz, 
previously carefully disinfected. The liquid obtained by this 
method like serum, had a slightly citrine color, was viscous, had 
an alkaline reaction and a fresh, not unpleasant sui generis odor. 
Left in a glass tube, it becomes transformed into a mass resem¬ 
bling coagulated albumin, and when the glass is agitated, the 
liquid disappears entirely. 
Comparing it with the virus taken from an old vesicle, this is 
found to be of a dirty white color, cloudy, with an acid reaction, 
with a strong and disagreeable odor. It contains impurities and 
