FOOT AND MOUTH DISEASE AND ITS MICROBE. 
307 
detritus, which collects at the bottom of the glass, and does not 
disappear when it is agitated. 
Seen under a microscope, the pure liquid is found to be com¬ 
posed of epidermic cells, red corpuscles, white corpuscles, fat 
cells, protoplasmatic granulations, and numerous vibrios micro - 
cocci , with well marked browmian motions. 
In the old virus, besides all the above, Dr. N. found numerous 
purulent cells, cellular organic detritus, rudimentary forms of 
bacterium termo or bacillus of putrefaction. 
In using coloring tests, such as fuschine, violet of gentian, etc., 
Dr. N. observed that the morphological elements become more 
apparent and that numerous microbs could be detected, which 
were those of epizootic aplita. Their diameter is very small; at 
first sight they resemble those of chicken cholera, discovered by 
Pasteur, but differ from them in some points, mentioned later on. 
Perfectly round, strongly reflecting light in their center, their 
outlines are well defined. They are generally single, seldom 
grouped by two, three or four, never in chapulet form. With 
very high power, by close observation the various steps of repro¬ 
duction can be seen. Some of them have a kind of granulation 
which becomes more and more apparent as it grows to the dimen¬ 
sions of the microbe from which it arises. This microbe with 
granulation then assumes an elongated shape; then between the 
granulations and the primitive microbe, a contraction or fissure 
and the body assumes the shape of figure 8, which is in fact, two 
microbes united together by a thin membrane which soon breaks 
up very readily by the simple motion of the fluid. These mi¬ 
crobes are also seen in the epidermic cells and the leucocytes. 
To be certain of the parasitic nature of these microbes, Dr. N. 
treated them with acids, alkali, ether and iodoform. But these 
actions, instead of causing their disappearance, intensified their 
appearance, though they seem to have lost some of their energy. 
Mixed with the bacteridesof putrefaction, they seem to experience 
no effect from it, and even their multiplication proceeds Aitli 
scarcely any interference. They disappear only when the bac- 
terides of putrefaction are very abundant. 
Placed in proper media, the microbe of foot and mou-th disease 
