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EXPERIMENTAL PATHOLOGY. 
EXPERIMENTAL PATHOLOGY, 
OF ALTERATIONS IN THE PULMONARY STRUCTURE OF DOGS BY 
THE INHALATION OF THE SPUTA OF PHTHISIC PATIENTS, 
AND OF OTHER ORGANIC SUBSTANCES. 
By W. Wargunin. 
Although the idea of comparing the pulmonary lesions pro¬ 
duced by the inhalation of the sputa of phthisic patients, and of 
other organic substances, originated with Prof. Manassein, it was 
in the laboratory of Prof. Rajewski that the researches were prose¬ 
cuted. 
The method by which the author aimed to secure the desired 
results was the exposure of a dog to the constant inhalation of an 
infected vapor, the animal being placed in a box properly con¬ 
structed to insure thorough passage of the vapor employed in the 
experiments. This vapor was charged with a liquid contain¬ 
ing, in a pulverulent form, the sputa of phthisis taken from em¬ 
physematous patients, mixed with cheese and flour, and the dog 
was thus confined to an atmosphere fully charged with solid par¬ 
ticles of infected matter. In some cases the sputa had been dis¬ 
infected with phenic acid. The liquids that were to be pulverized 
were of a milky consistency. Between the experiments, the dogs 
were placed in cages exposed to free air. 
In a first series of experiments, the pulverized liquids contain¬ 
ed the sputa of phthisis, diluted and filtered through linen to 
remove the coarser particles. 
The entire eleven dogs submitted to these tests presented pul¬ 
monary lesions. 
In a second series, the liquid contained sputa, which the au¬ 
thor had tried to sterilize by the addition of two parts of phenic 
acid to 100 of the filtered liquid, and by boiling it three times at 
intervals of two or three minutes. Similar lesions were again 
obtained. 
In a third series, the pulverized liquid, containing either sputa 
of emphysematous patients, cheese or flour, furnished the same 
results. The author concludes that these lesions were not the re¬ 
sult of a specific element. 
