PATHOLOGICAL PHYSIOLOGY. 
459 
PATHOLOGICAL PHYSIOLOGY. 
PROGRESS OP THE LESIONS FOLLOWING THE INOCULATION OF 
TUBERCULOSIS OF MAN TO THE RABBIT AND GUINEA-PIG. 
APPLICATION TO THE STUDY OF INOCULATION AND RE¬ 
INOCULATION OF TUBERCULOSIS. 
By M. S. Arloing. 
First .—The progressive invasion of the lymphatic system by 
infectious substances which enter the economy by effraction; the 
inflammatory swelling of the glandular chaires, marking out, as it 
were, the road followed by the virus, are notions long since 
accepted in pathology. In late years, Colin and Toussaint have 
made special applications of these items of knowledge—the first 
to the mode of progression of the tuberculous virus, the second 
to the determination of the seat of infection of anthrax. Still, if 
the infection of the organism generally takes place in this man¬ 
ner, it would be wrong to believe that it also always proceeds in 
that manner in all domesticated animals. 
Among the numerous inoculations which we have for some 
time been making in the study of the relations that may exist 
between huma \ tuberculosis and scrofula, we have observed inter¬ 
esting differences between the propagation of the tuberculous 
process in the rabbit and in the guinea-pig, which are quite 
worthy of consideration. 
Second .—Several authors have already remarked the excessive 
sensibility of the organism of the guinea-pig to tuberculous virus; 
but no one, we believe, has insisted upon the relative weak recep¬ 
tivity of the rabbit. If we study the facts in two groups of 
guinea-pigs and rabbits, simultaneously inoculating with propor¬ 
tional doses of virus, we shall discover that after two months all 
of the former will present numerous and extensive signs of gen¬ 
eral infection, while amongst the rabbits a portion of them will 
escape the effects of inoculation altogether, while others will have 
lesions less numerous than those of the guinea-pigs, and perhaps 
only a single pulmonary tubercle. Instead of becoming tubercu¬ 
lous by almost everything, as it has been stated, the rabbit offers 
a comparatively powerful resistance to the virus of human tuber¬ 
culosis. 
