10 
GEORGE FLEMING. 
I 
the jaw. The month was kept half open, and a little saliva 
flowed from it; the tongue was healthy, and nothing amiss was 
noticed on the left side or roof of the cavity. The fourth and 
fifth molars of the right side were pushed upwards by the growth 
of the tumor, and were a little separate^ from the adjoining 
teeth. The mucous membrane of the mouth was healthy, and 
the gums were not separated from the teeth. There was no 
swelling in the intermaxillary space, nor towards the neck. The 
jaw could be moved passively. The disease was diagnosed as 
osteo-sarcoma, probably complicated with mycloplaxy. 
In view of the rapid growth of the tumor and the local and 
general condition of the animal, as well as the improbability of 
palliative, surgical or pharmaceutical measures being of any avail, 
resection of the diseased portion of the jaw was made, and 
though for some time the prospects of recovery were favorable, 
yet the dog ultimately succumbed rapidly. 
The major portion of the tumor was hard and fibrous, and had 
a reddish-yellow tint at the inferior part, whitish elsewhere. At 
the lower curvature the neoplasm became suddenly and regularly 
lobulated, the connective tissue forming the interlobular spaces 
being continuous with that composing the envelope of the tumor 
as a whole. The inferior third of the section showed multitudes 
of yellow points, irregularly disseminated throughout; there were 
none in the upper part. The tumor and its fibrous envelope 
were very slightly vascular. When examined microscopically, 
the most important feature noted was the presence of numerous 
disseminated Actinomycetes masses, especially towards the infe¬ 
rior part; they were only casually met with in the upper portion, 
while deeper in the tumor they were very definite, in outline and 
enclosed in a kind of nucleus composed of apparently dead tis¬ 
sue. Many of these radiate fungi did not show the slightest 
trace of calcification, others were completely invaded by lime 
salts, and the nodules enclosing them had to be treated with hy¬ 
drochloric or nitric acid before their contour could be well defined. 
The fungus appeared in two rather different forms, or rather 
aspects, which probably depended upon its stage of growth. Cut 
in the direction of the sarcomatus tissue, intermediate to the 
