56 
GEORGE FLEMING. 
cellular fibro-sarcomatous growth, in which the gland structure 
was limited to a few small masses in the midst of the new forma¬ 
tion. The teats were partly normal, partly effaced by retraction 
into the tumor, and partly grangrenous and fissured. In the mass 
of the tumor were found a small number of well-defined nodules, 
from the size of a hazel-nut to that of a fist. The smallest of 
these contained a greyish-yellow or reddish mass, resembling 
brain tissue, with yellowish colored nuclei interspersed through¬ 
out. In the centre of the largest the matter appeared to be un¬ 
dergoing caseous degeneration, and in some of the interspaces was 
a greenish-yellow, thick, puriform fluid. The milk system was 
markedly altered. In places it was smaller and larger, and near 
the centre of the tumor it was flask or flagon-shaped, its outline 
being sharply defined, and the dilatations being filled with the 
typical spongy tumor mass. 
In the case produced by inoculation, reference to which will 
be made hereafter, the most interesting fact is that the Actino¬ 
myces was introduced into the gland by its milk duct, and that the 
inflammation set up in the mucous membrane, which was at first 
adventitional, became interstitial—affecting the intra-acinous con¬ 
nective tissue, and producing intensive development of the glan¬ 
dular parenchyma, with, finally, extreme hypertrophy of all the 
connective tissue. 
Ponfick had sent to him the udder of a sow which had been 
affected with erysipelas ( Rothlauf ), but there was such an un¬ 
usual disappearance of the proper gland tissue, and altogether the 
lesions were so different to those brought about by that malady, 
that the existence of another disease was suspected. 
In the middle of the largest half of a round swelling involving 
the entire mass of the mammae, and which was double the size of a 
child’s head, were noticed a great number of soft, round nodules, 
fixed here and there in the lardaceous-looking substance of the tu¬ 
mor. This felt so peculiarly elastic, and was at the same time 
so compact, that on pressure on the surface it seemed as if the 
fluctuation was due to some deep-seated gelatinous fluid. This 
was enclosed in a white, dense, inelastic tissue, on the inuer sur¬ 
face of which were some detached portions of the gland proper, 
