ACTINOMYK08IS. 
205 
points. On section from the periphery towards the hilum it 
was noted that each white point on the surface was prolonged 
towards the medullary surface by a white line. Examined micro¬ 
scopically, in all these nodules the mycelum was found to be 
felted and already undergoing destruction. In rabbit No. 1 the 
mycelium tubes were yet perfectly recognisable; they were felted 
and partitioned, and in every respect similar to those figured by 
Grawitz. In rabbit No. 2, the one that lived a day longer, the 
mycelia had almost completely disappeared. Some fragments 
were noticeable which were easily broken up. 
“In the liver there were also numerous white points, which 
contained fragments of mycelia in process of destruction. The 
lungs showed a small number of white nodules, but no mycelium 
tubes could be discovered in them, only granules which were 
doubtless the product of disintegration of the mycelia under the 
influence of the inflammation its presence provoked in the lung 
tissue. Similar white points to these were also found beneath the 
pericadium and in the walls of the stomach. 
“ In these two rabbits, the spores of aspergillus glaucus , cul¬ 
tivated on bread which had an acid reaction, produced a mortal 
infection exactly similar to that which Grohe and Block obtained, 
and also like that induced by Grawitz, with their malignant 
varieties previously adapted to the character of the blood by 
gradual cultivations. 
“ The spores which I injected into the rabbits did not undergo 
any process of adaptation to enable them to live in the blood ; 
nevertheless, they germinated and vegetated in the organism. 
Previous adaptation is therefore needless in order to render the 
spores of aspergillus glaucus infective.” 
Kaufmann alludes to the experimental results published by 
Koch and his assistants, Lcefller and Gaffky, and which are anal¬ 
ogous to those obtained by himself. These German investigators 
believed they had discovered the cause of Grawitz’s non-success. 
Finally, he arrives at the following conclusions:— 
1. The aspergillus glaucus grown on bread may produce 
fatal infection in the rabbit, even in an extremely small dose, 
1.10th of a milligramme. Subsequently it was found that 0.05 
milligramme of spores was sufficient to kill large rabbits. 
