498 
R S. HCIDEKOPER. 
duce the local and general infection, but a less quantity (1-10 
drop) causes no local lesion, while tumors may appear elsewhere; 
less still (1-15 drop) creates a general disturbance and confers 
immunity. 
Virus injected directly into the veins in almost any quantity 
(under ten drops) causes a general fever only. 
Into the respiratory tract the effect is the same, and the ex¬ 
periments of feeding virus with hay, oats, milk, etc., were all 
negative. 
Mechanism of the Infection. —The infection is produced 
through the blood (including the respiratory apparatus) and the 
connective tissues, and results in an incomplete and curable 
disease, or in a complete disease with a fatal termination. The 
endothelium is evidently a barrier to the microbes, as they mul¬ 
tiply in the blood and only produce tumors when a lesion is made 
for their exit. In the connective tissue the microbe finds a favor¬ 
able field for pollution, and, after dissemination by the blood or 
lymphatics, any traumatic lesion favors the development of a 
secondary tumor. 
Infection by the lungs must be regarded as the same as by 
the blood, and this is probably the most common mode of infec¬ 
tion in the so-called spontaneous origin of the disease. When by 
accident, wound or otherwise the microbes, in sufficient quantity, 
gain the connective tissue, they develop rapidly and cause a 
tumor as the first symptom and we have the “essential anthrax” 
of Chabert; when, on the contrary, they have developed in the 
blood and by endothelial lesion find access into the connective 
tissue, we have the local trouble follow a general fever and the 
“ symptomatic ” form of the disease is present. 
Experimental proof that the microbe of hacterian anthrax is 
the exclusive agent of the virus. —The virulent humors were 
innoxious after filtering in plasfer-of-paris. The filter was viru¬ 
lent. Diluted humors after standing sixty hours were virulent 
only in the lower stratum, wker^microbes were found. After 
“ essential anthrax ” the blood is not virulent until microbes can 
be found in it. 
The granulations or brilliant spores found in the blood 
