516 
PATHOLOGICAL PHYSIOLOGY. 
as to where the virus is obtained. Glanders produced in the guinea- 
pig by the inoculation of the cultures is absolutely the same in a 
chemical and anatomical point of view, with glanders produced 
in the same animal from glanderous products taken directly from 
the horse. 
These experiments are sufficient, both as to their number and 
agreement with one another, to justify the conclusion that there 
exists in glanders a living element, isolable from the matter in 
which it exists, by means of its culture in an appropriate medium, 
where it appears in large quantities under the form of a movable 
baccillus, which is incontestably the instrument of the virulency 
of glanders, inasmuch as the drop taken from the liquid of the 
fifth, sixth, seventh, or eigtli culture, is as capable by its introduc¬ 
tion into a susceptible organism of giving rise to glauders as the 
natural virulent matter, taken directly from a glandered animal. 
Your commission might be content in the presence of such evi¬ 
dent demonstration with an expression of their acquiescence in the 
conclusions of Messrs. Bouchard, Capitan and Charrier. But we 
have thought that on such a subject, “ quantity would not spoil 
quality,” and your reporter has taken advantage of the means at 
his disposal for the verification, experimentally of the results ob¬ 
tained by those gentlemen, who willingly accepted the offer to 
renew their (^periments under the conditions which were sub¬ 
mitted to them. 
On the 20th of August, 1883, a horse and a mare were de¬ 
stroyed in their presence. These animals had all the external 
symptoms of glanders ; gland discharge, with nasal chancres ; and, 
as revealed at the post mortem , the special ulcerations of the 
pituitary membrane and pulmonary lesions, under the form of 
nodosities and tumors, though more developed in one subject 
than in the other. 
There was no doubt as to the nature of the disease; it was 
acute glanders. 
Vases for culture, ready prepared, immediately received the 
products obtained from the two animals; matter from the lym¬ 
phatic glands and from the pulmonary abscesses ; blood from the 
heart; and purulent discharge found upon the surface of the 
chancres. 
