518 
PATHOLOGICAL PHYSIOLOGY. 
stuffed with nodules of a yellowish white tint, the size of a hazel¬ 
nut, or of small nuts, projecting and giving to the surface of the 
lung a bosselated aspect, made more evident by the depression 
under atmospheric pressure, of the healthy structures of the sur¬ 
rounding pulmonary tissue. 
These nodules gave to the touch well-marked sensations of 
compactness, and had a caseous consistency. 
JNo effusion appeared in the pleura, pericardium or peritoneum, 
and no lesion appeared in the laryngeal, tracheal or bronchial 
mucous membrane. 
There were two ulcerations upon the pituitary membrane in 
the left nasal fossa; a smaller one upon the middle of the sep¬ 
tum; and another and larger, also upon the septum, but higher 
up. The lymphatic glands of the subglossal region were en¬ 
larged, and were the seat of serous infiltration. On the surface 
of the spleen there were seven nodules, one of which was quite 
large. 
All these lesions being sufficiently characteristic of the special 
object in view, further investigation became unnecessary, espe¬ 
cially in view of the dangers attending the work of the post¬ 
mortem in cases of such extreme activity as the subject under 
notice had developed. 
Donkey No. 2 .—Inoculated with the liquid of the sixth culture .' 
This animal was inoculated on the same day, in the same manner 
and in the same place. 
The local and general symptoms were about the same as 
those of the first case, but the disease was of longer continuance, 
by five days. Death took place in the night of the 9th of Sep¬ 
tember, the post-mortem being made on the 10th. The pulmo¬ 
nary lesions were less marked than in the first animal. There 
were but about twenty small, compact nodules, surrounded by a 
hemorrhagic zone, and nothing appeared in the spleen or in the 
liver. There was infiltration of the aryteno-epiglottic folds, and 
an irregular ulceration, not deep, about three centimeters long 
and two in width, in the middle of the left arytenoid cartilage. 
In the nasal cavities were four well-marked chancres, on the left 
face of the septum, one of them being quite large. The entire 
