520 
PATHOLOGICAL PHYSIOLOGY. 
for disseminated inflammatory processes, and from which the 
modifications of culture followed. 
This theory—we may say it to-day—was a presentiment of 
genius, but the irritating thorn, admitted by the hypothesis, is 
to-day a living reality. It is the microbe, or rather the thousands 
of microbes, which, concentrated in a given point of the paren¬ 
chyma, or of the mucous membranes, give rise by their presence 
and their vital activity to the irritating action of which the ex¬ 
pression is the formation all around them, of a fluxus and a con¬ 
secutive inflammatory process. With this idea, the formation of 
the inflammatory nuclei, characteristic of the anatomical develop¬ 
ment of glanders, places itself under the great law of the com¬ 
manding fluxus, or to better express it, under the law which 
regulates the connections of the organic network with the bodies 
which are foreign to it, and penetrate into it. 
{To be continued .) 
PREVENTIVE INOCULATION WITH CARBUNCULAR CULTURES 
ATTENUATED BY THE METHOD OF RAPID HEATINGS. 
By M. Chauveau. 
The author uses the process of double vaccination, introduced 
by Mr. Pasteur. He says, this is the most convenient way to op¬ 
erate. “ Instead of heating in a single mass all the liquid called 
vaccinal , contained in each mattrass, I divided it in two equal 
parts, one being heated to -f- 80°, the other being kept as it was. 
This last, with its weak primitive attenuation, is in the best con¬ 
dition for the vaccination that Mr. Pasteur calls the second, the 
former, whose attenuation is completed by the heating at -f- 80° 
being used for the first vaccine.” 
The experiment was made upon ten sheep. After the first in¬ 
oculation, none were apparently sick and none died. The second 
inoculation was postponed on acconnt of various circumstances, 
and was made only two months after the first. Nevertheless, it 
did not seem to disturb the animals any more. One, however, 
died afterwards of splenic apoplexy. Then the testing operation, 
the inocnlation with very strong virus of a normal culture, was 
