522 
PATHOLOGICAL PHYSIOLOGY. 
hud been attributed to the density of the cellular tissue of that 
region, and the experiments of the authors tend to prove that to 
that cause must be added the low temperature of the extremity of 
the tail, comparatively to that of the rest of the body of the ani¬ 
mal. Indeed, in heating or cooling the tails of animals in experi¬ 
ments, the effects of the inoculation were either increased or di¬ 
minished. The conclusions arrived at were : 
First —That the temperate seasons are the best for the prac¬ 
tice of preventive inoculation. 
Second —That it must not be done in summer. 
Third —That if one is obliged to inoculate in the winter, the 
success- of the operation will be increased by keeping the animals 
during the first days, in stables where the atmosphere is warm.— 
Gazette Medicate. 
ORIGIN OF VACCINE. 
Mr. Wahlomont, (of Brussels,) in a paper upon the origin of 
vaccine, concludes that : 
First. —Equines and bovines and no other animals can be con¬ 
sidered as vaccinogenous. 
That neither the horse nor the cow can create of themselves, 
the former the liorse-pox, the latter the cow-pox; that both, to 
furnish a vaccinal matter, must have first received the seed of it. 
Second. —The original sowing of vaccine, in its relation to 
the horse or the cow is nothing else but variola, which upon be¬ 
ing introduced into the organisms of these animals, undergoes an 
attenuation which modifies it into that which we call vaccine. 
Third. —This attenuation is less in the horse than in the cow ; 
horse-pox therefore, is nearer to variola than cow-pox. 
Fourth. —The horse is a poor medium for the culture of vac¬ 
cine matter. Animal vaccination requires germs attenuated to a 
higher degree than those that can be found in the horse. 
Fifth. —Variolic impregnation or artificial vaccination in the 
horse, by inoculation, or intra cutaneous injection, seems to be 
susceptible of development in the cow without external manipu¬ 
lation. Immunity must be the consequence of this impregnation. 
— Gazette Medicate. 
