27 G 
CHARLES F. RING. 
fection (?) It never occurs as a termination of acute glanders. 
Its period of incubation is uncertain, and lias been stated to vary 
from a few days to a year.” 
A description of the chancre of glanders reads very much like 
that of syphilis, to wit: u The chancre of acute glanders may 
sometimes cicatrize, but the mucous membrane is never regener¬ 
ated at the spot it occupied, being replaced by a very dense white 
tissue, thicker than the membrane for which it is substituted, and 
it consequently stands above the surrounding level; the cicatrix 
is composed of fibres which radiate from the centre towards the 
circumference in a stellate fashion. The presence of this indel¬ 
ible cicatrix always betrays the loss of substance that has taken 
place in the membrane.” 
Again, “ the chancre is sharply cut in the membrane as if it 
had been stamped out by a punch; this is surrounded by a very 
narrow indurated border, and has a hard resisting base , the bottom 
being gray and unhealthy looking; the characters of the borders 
and centre being due to the continual production of new cells.” 
(Fleming, ibid , p. 510.) As a knowledge of glanders in the 
human subject is more important to the present discussion, we will 
proceed at once to a consideration of it. 
GLANDERS IN THE HUMAN SUBJECT. 
“ No connection had been traced between the terrible diseases 
in the lower animals which have been briefly described and an 
affection which then, as now, must have occasionally affected 
those who had charge of horses suffering from glanders and farcy, 
until the year 1810, when Waldinger drew attention to the fact 
that special precautions ought to be adopted in the dissection of 
horses affected with glanders and farcy, inasmuch as the direst 
consequences, even death, might result from the inoculation of 
the purulent matter. The accuracy of the statements of Waldin¬ 
ger was supported by the publication, in 1812, of a paper by a 
French military surgeon, Lorin, who, under the title “Observa¬ 
tions sur la communication du farcin aux Homines,” described 
the case of a veterinary surgeon who, having accidentally pricked 
himself whilst operating upon a glandered horse, suffered in con- 
