AN INQUIRY. 
277 
sequence from inflammation of the hand. The statements of 
Waldinger do not, however, entitle him to be considered the first 
person who pointed out that glanders is communicable from the 
lower animals to man, for although he stated that dangerous con¬ 
sequences might result from the inoculation of the purulent mat¬ 
ter of glanders and farcy, he did not state that the affection in¬ 
duced in man in any way resembled that of the horse.” (Gamgee, 
ibid, p. 186 .) 
u The stage of invasion, or the premonitory stage, commences 
with a feeling of indisposition or depression, and with peculiar 
wandering pains, followed by febrile excitement, shivering, great 
heat and uneasiness ; soon afterwards there is pain affecting the 
muscles, simulating rheumatism and often mistaken for it. The 
pain generally .attacks the extremities, and more especially the 
bend of the groin, the axillae and neck, where upon careful and 
minute examination swellings may be detected, which are some¬ 
times diffused and sometimes circumscribed, indicating glandular 
complication ; these may disappear suddenly or be altogether ab¬ 
sent. The fever soon assumes a more inflammatory character, 
the pulse being full 92-96, the skin is hot and dry, the face 
flushed, and the head heavy; there is want of sleep, the tongue 
is foul, the urine scanty and high-colored. Sooner or later, the 
second stage, that of eruption, takes place and at once develops 
the specific character of the disease. In acute cases this appears 
almost at once soon after the invasion, but in chronic cases there 
may be an interval of weeks. The eruption consists of a crop of . 
pustules, remarkably hard, resembling the smallpox, and attack¬ 
ing the skin like an exanthem; it is said to be specific and path- 
ognomous of the disease.” (Holmes’System of Surgery, Vol.I, p. 
701.) 
Two interesting plates accompanying this description illus¬ 
trate this eruption well. Immediately on seeing it one is reminded 
of the vulgar name “ big pox,” which was at various times ap¬ 
plied to the epidemic. 
Also in these same plates are shown subcutaneous tumors, 
which remind one very much of descriptions of syphilitic gum- 
mat ae ; they are possibly the so-called “ farcy sores,” or “ buds.” 
