278 
CHARLES F. RING. 
Gamgee writes: The disease is usually ushered in by feelings 
of lassitude, headache, and rigors, frequency of the pulse, and 
often by vomiting and diarrhoea. Articular and muscular pains 
occur from an early period of the disease, and increase during 
its progress. The limbs and body become the seat of subcuta¬ 
neous abscesses, which are frequently found on the face and near 
the articulations. A remarkable pustular eruption generally ap¬ 
pears on the surface of the body, being specially found on the 
cheeks, arms and thighs.” (Hid, p. 189.) 
Let us review here, by way of comparison, a few of the 
symptoms of the “ epidemic” which we have already consid¬ 
ered. 
9 
“ The prevailing epidemic,” writes Petrus Pintar, “ is charac¬ 
terized by a variety of symptoms, more particularly by keen and 
excessively violent pains. Some do not have any pains, in the 
place of which they are attacked by pustules of various shapes 
and sizes, being very numerous on some individuals, and on 
others more scanty. Sometimes the pustules break out only in 
the face or on the head, while the other parts of the body re¬ 
main free ; in other cases they are only seen on the abdomen ; 
most frequently they break out on the thighs and legs, but may 
likewise spread over the whole body. Grenbeek states that the 
disease commenced with langour and debility of the limbs*, after 
which the pustules broke out with intense fever; he adds, that 
whenever these pustules or tumors burst open they sometimes be¬ 
came converted into frightful phagadenic sores. 
“ The pains accompanying this eruption are sometimes so vio¬ 
lent that the patients are deprived of their sleep for forty, sixty, 
and even a hundred nights together, after which the pains like¬ 
wise assail the head. Others experience in their shoulders an in¬ 
describable feeling of stinging and weight; others again, experi¬ 
ence the same pain in the elbows, knees, even in all the limbs and 
joints at the same time, so that they are unable either to walk or 
to stand, and have to abandon every kind of work.” 
Put to return to glanders in the human subject. “Among 
the less frequent concomitants of the disease may be also men¬ 
tioned specific tubercles and abscesses of the glanspenis, testicles 
