332 
CHARLES F. RING. 
new appeared externally, but in live months after the inoculation 
the strength of the animal failed and it died. Under the site 
occupied by the papules during life, although no deeper seated 
disease had then been detected at these points, the skull showed 
evidences of periostitis and of caries sicca—exactly such changes 
as are found in man due to syphilis. 
u A focus of interstitial fibrous thickening containing spindle 
cells was found in the lungs, the pleura being extensively thick¬ 
ened over it in a radiate manner. Certain new formations of 
cells, resembling young syphilomata, were found in the kidneys, 
hinally, some blood taken from this ape yielded plants looking 
very much like the fungus which had been inoculated upon the 
fiist ape. Other animals, besides the apes of Klebs, have been 
successfully inoculated with pieces of chancre or its secretion— 
guinea pigs (Legros, Bradley), monkeys (Depaul), cats (Vernois, 
Bradley)—and ulcers and gummata produced, leading to maras¬ 
mus and death.” (Keys, ibid , p. 62.) 
It is an established fact that these same animals are not very 
susceptible, even to the poison of glanders. Fleming writes: 
‘‘With regard to species, it is established that mankind, dogs, 
sheep, goats, rabbits and mice can be successfully inoculated with 
glanders. JSIext to the equine and asinine species (in which the 
malady runs its course most rapidly), with regard to susceptibility, 
comes the feline, canine and the human species. The receptivity 
of the dog is not very great; indeed,not many years ago inocula¬ 
tions with glander virus were so unsuccessful in this animal that 
it was believed it could not be infected.” (Ibid, p. 533.) 
Another point of resemblance between the poison of glanders 
and syphilis that may be suspected is this—that while the dog is 
perhaps one of the most convenient of animals to experiment on, 
and is infected with glanders with difficulty, it is noteworthy that 
syphilis—a milder disease—is not mentioned as having been 
communicated to it; while the cat—more susceptible to glander¬ 
ous inoculation—has been successfully infected with the syphilitic 
poison. 
But to return to our main subject again. 
