tt. S. HUlT)EK 0 r J 15 ft 
m 
quent and difficult respiration; at times marked dyspnoea, some¬ 
times gaping; salivation and continued licking with the tongue ; 
in some cases an inconsiderable elevation of temperature; increase 
of peristalsis during one to two hours; lively intestinal murmurs, 
audible at several paces; copious voiding of intestinal gases and 
excrement; the excrement changes later to a pap-like and often 
to a fluid consistency. 
The introduction of greater (toxic) doses into the circulation, 
induces tetanic contractions of the extensors of the hind legs, 
tetanic contraction of the intestinal muscles, groaning from 
the pain, great debility and transitory relaxation of the sphincter 
ani. 
When a full dose of the remedy is applied subcutaneously , 
the first symptoms are observed in twenty to forty minutes. 
Slight trembling of the skin at the point of injection, and 
later over the whole body; repeated gaping, active peristalsis, 
repeated voiding of gas and excrement, which continues for about 
three hours; increased salivation and continuous licking. 
Frequency of respiration and dyspnoea, as well as elevation of 
temperature, generally lacking after the subcutaneous injection, or 
are but trifling. 
In many horses, small doses injected subcutaneously have no 
perceptible effect; in others, peristalsis becomes more active in 
about an hour, and in two to three hours the horse voids a large 
mass of excrement. 
The action of physostigminum extends over the whole intes¬ 
tinal tract. 
As the remedy in suitable doses has no excessive action, it is 
especially fitted for the treatment of grave stomach* and intestinal 
disorders of horses and cattle. 
It is evident that physostigminum should not be used where 
the intestinal muscles have lost their excitability in the colics due 
to impacted matter or great meteorisation. 
The dose of physostigminum sulfuricum is, according to Pro¬ 
fessor DieckerhofPs experiments, from 0.04 to 0.10 grammes, 
according to the size of the horse. 
A one per cent, solution is the most suitable, either for sub¬ 
cutaneous or intravenous injection. 
