530 
GEORGE FLEMING. 
the mouth or palatine sinus. The bones, when macerated, looked 
like pumice-stone, modified through central osteoporosis and 
external hyperostosis. After some time the round, conglomerate? 
luxuriant growths generally became puriform or ichorous, and 
ulcerated, producing abscesses and fistulse, and sometimes increased 
to the size of a child’s head. The progress of the disease was 
gradual, and interfered with mastication when it had advanced to 
a certain stage; this led to emaciation, and to prevent loss from 
this cause the owners of the cattle generally had them destroyed 
before this stage was reached. In examining fresh tumors, Bol¬ 
linger discovered (in three cases) amongst the dense connective 
tissue, conglomerate masses or nodules of various sizes, from that 
of a walnut to a hen’s egg, of soft consistence, pale yellow color, 
and moist appearance, which on section showed a turbid, whitish- 
yellow puriform contents; or the nodules were of a spongy tex¬ 
ture, in the line stroma of which were numerous spaces about the 
dimensions of a hemp-seed, containing a dull-yellow, thick, or 
cheesy-like substance. In scraping a section of an old or young 
nodule, this substance was easily removed. Microscopically, the 
tumors appeared to be composed for the greater part of old or 
embryo granulation tissue, which had a kind of sarcomatous 
structure, while the cheesy substance consisted of pus-corpuscles, 
granulation and granular cells, as well as fatty granular detritus ; 
in addition, the latter contained innumerable, various-sized bodies, 
which were opaque, of a faint yellow tint, often somewhat mul¬ 
berry shaped in outline, and here and there encrusted with lime 
salts. This was recognised as a real fungus, but at first no patho¬ 
logical importance was attached to its presence, and' the disease 
was simply named “ jaw-osteosarcoma.” 
Besides this noteworthy form, which appeared to have its ori¬ 
gin in the invasion of the alveoli by the fungus, the tongue of the 
ox presented another form, proper to itself. Imbedded in the 
parenchyma of the organ, Bollinger found a greater or lesser 
number of nodular-looking bodies, the majority of which were as 
large as a millet or hemp-seed, and some as big as a cherry or 
walnut; many stood prominently from the surface of the mucous 
membrane. When fresh, they were mostly white or greyish- 
