EXTRACTS FROM FOREIGN JOURNALS. 
27 
able from lymphyid elements, undergoes necrobiosis, and a struc¬ 
tureless mass is the result. In the glander ulcer, this detritus 
escapes, and the process may be observed in progress at the 
periphery of the ulcer. 
The other nodular formations, which are surrounded by the 
inflammatory zone, are less firm, possess a perfectly round form, 
and the fibrous tissue at the periphery resembles, and in reality is 
the middle layer of the vessel. This vessel surrounds a fibro cellular 
mass, and much resembles a small clot. If we examine several of 
these nodules, in various stages of their development, we shall 
find an accumulation of blood cells at the periphery, (the red zone) 
and frequently extravasations into the surrounding tissue (dark 
red or black zone), with inflammation, i. e., an escape of the 
white blood-corpuscles out of the capillaries, which may be seen 
surrounding the nodule, in the walls of the vessel and in the 
fibrous tissue outside the vessel, forming a fibro-cellular mass. 
New blood-vessels are formed, and pass into this newly formed 
mass, and into the wall of the old blood-vessel. The fibro- 
cellular mass, as well as the clot-like portions in the centre, 
now separate with small irregular portions between the spaces of 
which the new blood-vessels penetrate ; in fact we may say we 
have an organized thrombus. At a later stage the whole becomes 
vascular and nutritious, and the leucocytes which normally escape 
from the vessels into the surrounding tissue alter their shape and 
send out processes and form a new connective tissue. Consequently 
the red zone which formerly surrounded the nodule becomes 
lighter in color, and at a still later period, instead of a nodule sur¬ 
rounded by a red zone, we find a firm, tense, greyish-white nodule, 
composed of fibrous tissue. In this case it will be seen the pro¬ 
cess is progressive, whereas, in the case of the glanders nodule it 
is retrogressive. It, therefore, appears to us that we are not justi¬ 
fied in considering all nodules that may be surrounded by a zone, 
or that are white and firm, to be of a malignant element, and 
produced by the glander poison. Although other authors have 
drawn attention to these nodules in a similar manner, still I would 
particularly desire to draw attention to the process of vasculariza¬ 
tion and organization of the thrombus, and it is on this account 
