190 
PROF. DESSART. 
been more active, and greater principally in the parenchymatous 
organs and in the mucous and submucous structure of the in¬ 
testines. * 
The obliterations, which sometimes take place upon large 
surfaces, ( territories ) bring on disturbances in the general circu¬ 
lation. They furnish explanations of the internal localizations, 
which are observed in the different apparatus of the organism, 
especially in the form of infiltration of hemorhagic centers, etc., 
as well as the disoxygenation of hematies, which explains the dark 
aspect of the blood. But independently of these essential 
changes, there are others, entirely local, which show themselves 
at the points through which the parasite has entered the animal 
economy. They are stimulated by the phlogogenous action of 
bacteridies, and excite externally the production of various en¬ 
largements, more or less well defined, sometimes diffused and 
with an oedematous character, at least in the beginning. These 
tumefactions form the primitive external localizations; they are 
the malignant pustules properly. If they are excised or des¬ 
troyed in time, that is, before the entrance into the blood of the 
microbes they contain, the disease may be aborted. Frequently 
one may observe other localizations, also external, but con¬ 
secutive to the introduction of the microphytes in the blood-mass, 
and whose presence may be largely attributed to the bacteridian 
embolisms found in the peripheric capillary system. The de¬ 
struction or excision of these local consecutive alterations do not at 
all interfere with the progress of the general morbid process. 
As long as the microbes remain only in the net-work of the 
structure, where they have been deposited, their multiplication is 
comparatively slow, because this is not sufficiently rich in 
oxygen. But it is different, when, through lymphatic blood¬ 
vessels and rupture of the capillaries, they enter the current of 
• 
the blood. They then multiply rapidly and are transported to 
every point of the economy. This last multiplication takes place 
*Sce the Theorio generate de faction des bacteridies dans le cbarbon. M. Tons- 
saint, ioc. oit., chap. vi. 
