306 
M. H. TOUSSAINT. 
deadly virus itself to transmit immunity. Indeed, in the form of 
anthrax, known as symptomatic , which is so essentially different 
from the bacteridian charbon, they have succeeded in giving im¬ 
munity by the direct injection of the natural virus into the gene¬ 
ral circulation, through the veins, where its activity is reduced to 
such an extent that its entrance into the organism gives rise only 
to slight febrile phenomena which soon disappear. It is known 
that the injection of the similar virus into the subcutaneous tissue, 
or in the muscular structure proves very rapidly fatal .—Gazette 
Medicate. 
COMPARATIVE PATHOLOGY. 
IN RELATION TO THE IMMUNITY OF ANTHRAX. 
By M. H. Toussaint. 
According to Mr. Toussaint the duration of immunity is in 
direct proportion to the severity of the first attack, or, in other 
words, to the energy of the vaccine, and in inverse ratio to the 
resistance of animals. In proof; in August, 1880, lambs of 10 
to 20 months, as well as old ewes, were inoculated with very 
energetic virus, too much so indeed, as it killed several of the 
young subjects. In those which survived, as well as in the ewes, 
all the phenomena following the inoculation were very severe, 
but all have preserved their impunity to the present time—July, 
1881. 
At the same epoch, other lambs and ewes were inoculated with 
a much attenuated virus. The effect was very mild in the ewes, 
but was more serious in the young animals. They all resisted an 
inoculation made a month later, while a few of the ewes, reinocu¬ 
lated four months afterwards, died. The lambs to this day have 
preserved their immunity. 
Heredity of immunity exists for the lamb. Seven ewes vac¬ 
cinated in May, July and August, 1880, had lambs subsequently. 
Those inoculated in the first month of their life, as well as their 
mothers, resisted the disease. 
