354 
DR. JOLYET. M. D. BRUNET. 
nothing abnormal, but towards tbe end of the third day, microbs 
begin to be seen, and during the following days, they increase 
largely in number, and when the pigeon presents the manifest 
symptoms of the disease, the preparation shows myriads of moving 
microbs. 
The incubation corresponds with the development of the 
parasite; the invasion shows itself when it has multiplied, and the 
eruption coincides with its gradual diminution. The dry pus of 
the pustules contains characteristic microbs in great number, 
which like those of the blood, may produce the disease when in¬ 
oculated on healthy subjects. When, in a certain number of 
pigeons, the cutaneous eruption is completely absent, and when 
at the same time the other symptoms take place as in ordinary 
cases, post mortem examination reveals then a true intestinal 
pustulation. 
Dr. Jolyet considering that the blood and the lymph are pre¬ 
eminently the media of culture of the microbs of variola, either 
in animals or in man, has noticed that the examination of the 
blood often gives only negative results; when even the blood is 
almost healthy in appearance, the lymph is full of living microbs. 
Similar experiments, made on animals reputed to be unable 
to contract variola (dogs and rabbits) because they have no 
cutaneous pustules, have given identical results, that is, a charac¬ 
teristic pustulation of the microbs in the lymph, as they can pro¬ 
duce the eruption and complete variola in animals which take it 
naturally .—Bevued d? Hygiene. 
EXPERIMENTAL PATHOLOGY. 
UPON EXPERIMENTAL TUBERCULOSIS. 
By M. D. Brunet. 
The experiments of Mr. Toussaint upon the inoculation of 
tuberculosis have not proved sufficiently convincing to fully 
satisfy my judgment. 
I have observed, as others have done, that the inoculation of 
foreign substances, other than tubercles, in the sub-cutaneous 
