PATHOLOGICAL PHYSIOLOG Y. 
511 
lesions , by which tuberculosis was supposed to be characterized, 
are insufficient. To produce true tuberculosis in this way, sus¬ 
ceptible of being inoculated, I deny; experimerital tuberculosis 
remains an artificial fact. 
True tuberculosis, taken from man, cow, pig, or rabbit, can be 
reproduced in an unlimited number of series; constantly, with the 
absolutely identical characters , it may pass from one animal to 
another without failing in its effects. I will say more. It becomes 
more powerful and rapid in its action as it is oftener inoculated. 
I might show numerous facts of series whose experiments are 
preserved. At first tuberculosis required four to five months to 
kill a pig or a rabbit; actually with five series two months are 
sufficient. General infection having taken place after thirty-five 
days, if at that time an animal is killed and another inoculated, 
this will die before the first. 
It is especially in the tuberculosis produced by culture that 
the increase of virulency is observed. The serosity of the caseous 
ganglion of a cat, which died after an injection of culture, was 
inoculated to six rabbits; all became tuberculous. Forty days 
after one was killed ; he already presented pulmonary deposits, 
which were inoculated to six rabbits and a pig; the pig died in 
fifty-seven days, and one of the rabbits in sixty-eight. At the 
present time animals of the fifth series are sicker than those of 
the third. 
This is observed with the cultures; the fifth series are more 
abundant and rapid than the first, the tenth than the fifth. It 
seems that the microbe becomes acclimatized. A rabbit which, 
five months ago, received eight drops of an eighth culture in the 
jugular, has just died with a lung full of granulations, some also 
existing in the kidneys and the spleen. 
I may again cite a pig, inoculated with vaccine cultivated 
upon a cow, which had been killed, and presented a handsome 
generalized tuberculosis.— Gazette Medicate. 
