58 
M. L. TRASHOT. 
birth the disease may develop itself and run its course regularly 
or not, and in both cases protect the animal thus affected for a 
later period. 
Still, perhaps we should not, without hesitation inoculate very 
young subjects, on account of their lesser power of resistance 
to the disease. This question, I take the opportunity to say, cannot 
be actually or positively decided, and will not be unless further com¬ 
parative experiments are made. It may be possible that, with the 
object of preventing all accidental contamination, the effects of 
which are ordinarily most dangerous, sucking animals will be 
inoculated. However, from the facts, very few, it is true, positive 
as they are, which I have collected, I am assured that at the end 
of the first year animals can safely be operated upon. At that 
period the loss of time for work does not need to be considered ; 
a rather important question in an economical point of view. 
As always during the course of the disease, it is prudent to 
keep the animals at rest and in good hygienic condition, so as to 
protect them from exposure to cold or other influences likely to 
interfere with the pustular eruption, and give rise to the appear¬ 
ance of respiratory inflammations more or less serious. There may 
be, after all, great advantage in inoculating colts before they are 
broken for work. 
As to the time of the year, this seems to me to be of little in¬ 
terest. It is only when one operates upon animals living con¬ 
stantly out of doors that good weather is to be preferred. This 
is not the most general case. Horses, especially in our days, are 
kept more or less in-doors, and it is easy to keep them so during 
the whole duration of the disease. I am satisfied then, that inoc¬ 
ulation can be performed in all seasons of the year. I have 
often done it without noticing the slightest accident. 
In all cases after inoculation performed upon very young ani¬ 
mals not working yet, or upon adults, it is good to keep them at 
rest, to feed them moderately mid to protect them from all at¬ 
mospheric influences until the period of dessication of the pustules. 
With these precautions, after a slight fever, the pustules make 
their appearance more or less abundantly on the whole surface of 
the body, from the fourth to the sixth day after the operation, and 
