American Veterinary Review, 
OCTOBER, 1880. 
ORIGINAL ARTICLES. 
EXPERIMENTAL ANALYSIS 
OF THE MALIGNANT PUSTULE AND CARBUNCU- 
LOUS (EDEMA; DETERMINATION OF THEIR 
VARIOUS FORMS AND OF THEIR 
DEGREE OF VIRULENCY. 
By N. Colin, of Alfort. 
Observers who have industriously studied in man the acci¬ 
dents of local anthrax and most carefully generalized them, have 
failed to agree upon the characteristics belonging to malignant 
pustule. The descriptions they have given of it do not enable us 
to recognize it with certainty at its origin, nor even at a more 
advanced period ; it would almost appear to the reader th-t they 
refer to accidents of diverse nature and aspect. 
From my first researches in anthrax I was led to ask myself 
whether it might not be possible to produce by experimenting 
upon animals, the pustules and oedemas, which, followed in all 
their successive stages of evolution, would furnish some precise 
insight into their symptomatology and pathological anatomy. 
And in searching in this direction I have reached the conclusion, 
first, that on some species of animals no mode of carbuncular 
