EXPERIMENTAL ANALYSIS OF MALIGNANT PUSTULE, ETC. 261 
the neck that the oedema specially appears; it is under the abdo¬ 
men, inside the folds of the Hank, in all parts with thin, hairless 
skin, that the pustule is best developed ; it is in the groin that it 
is most often united with infiltration, erythema and bubo; it is 
on the internal face of the thigh that it is complicated with ex¬ 
tensive lymphangitis and is accompanied with sloughs and ulcera¬ 
tions, &c. It is in consequence of the differences in the nature 
of the ground where the virulent liquids are deposited, that the 
accidents of anthrax assume forms so varied. 
It is not my purpose to describe minutely all the forms I have 
named: I wish simply to precisely determine the character of the 
malignant pustule and of the carbuncular oedema, in all the steps 
of their evolution, and to show how these accidents in the animal 
resemble and wherein they differ from those of the human econo¬ 
my. When the carbuncular virus has been introduced in a punc¬ 
ture or scarification of the skin of a dog, in a hairless spot, most 
ordinarily in twenty-four hours there appears a conical elevation, 
red at its summit, and often in its whole surface, which is in an 
enlarged form, the analogue of the papula or small pimple de¬ 
scribed* as the beginning of the malignant pustule in man. 
This elevation has at its summit a small canal, from which either 
spontaneously or by pressure oozes a little slightly reddish seros- 
ity. A little later, say within thirty-six or forty-eight hours, the 
elevation has become much enlarged. It has attained the size of 
a small nut, or of an almond, spreading at the base, and is de¬ 
pressed, even umbilicated at its summit; its red color is more 
marked, its epidermis becomes raised in places, the exudation 
ceases, and with a serosity of small confluent phlyctenes resem¬ 
bling the vesicles of an orange peel, from which the pustule is 
formed. The fluid escaping from its large opening becomes of 
a bad aspect and remains serous for a long time, although having 
a tendency to become purulent. From this moment the pustule 
of the dog differs from that of man. In its center there is an 
opening, instead of the black spot which will form the slough, 
and at its periphery there is a greater or less degree of oedema 
developed. Once formed with its essential character, the pustule 
*By some and not by all observers. 
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