EXPERIMENTAL ANALYSIS OF MALIGNANT PUSTULE, ETC. 263 
bnncular accidents remain local, which in man become gen¬ 
eralized. 
Before proceeding further, we may observe that this carbun- 
cular pustule cannot develop itself in all parts of the body. It 
establishes and perfects itself witli its essential characteristics 
only in certain regions, as in parts covered witli a fine skin, almost 
hairless, with abundant cellular tissue, rich in lymphatic vessels, 
such as the inferior part of the abdomen, the axillae, groin, mam¬ 
mae, perinsenm, scrotum, in front of the pubis, and generally in 
the neighborhood of ganglions. This ground is especially favor¬ 
able for it in young subjects, where it may become as serious as 
in the human species. Still, while these localities are favorable 
to the development of the pustule, it does not always render it 
more dangerous. Ordinarily, the most voluminous pustules, with 
well marked inflammatory symptoms and with rapid development, 
end by resolution without giving rise to well marked general dis¬ 
turbance. On the contrary, very often, when the pustules are 
less prominent, without active irritation and of slow growth, the 
attacks are followed by diffuse oedema, ganglionar tumefactions, 
ulcerations, gangrene on large surfaces, or abundant suppurations 
and extensive sloughs. These last pustules, small in dimensions, 
as when aborted, if unaccompanied with large oedema, may be¬ 
come more frequently than the other variety, the starting point of 
a general infection. 
The varieties that carbuncular pustule presents, so far as its 
form, extent, rapidity of growth, and serious complications are 
concerned, are not all explained by reasons relating to the locality 
of their occurrence, while most of them are anatomical and 
physiological. These varieties have, at least, some of them, indis- 
cernable causes, as we meet with them not only in individuals of 
the same species placed in conditions apparently similar, but they 
may nearly all be met with in a single subject. Indeed, with a 
given carbuncular blood, deposited in a series of inoculations 
sufficiently scattered under the abdomen or on the line of the 
mammae, on the right and on the left, one may develop quite often 
almost all the forms that have been enumerated. Here an enor¬ 
mous pustule, very red, umbilicated, raised by a large oedema; 
