IMMUNITY AGAINST ANTHRAX. 
265 
ment always takes place in French breeds of sheep and in rabbits 
in sufficient force to produce death. It nevertheless thrives with 
difficulty, and as proof, one may say that it never reaches in the 
tissues or the liquids of an animal its complete period of develop¬ 
ment. It never produces spores; its multiplication always takes 
place by division of tlie mycelium. 
On the other side, some animals never take anthrax, though 
their condition of life seems like those of the species which take 
it witli the greatest facility—such is the pig. Finally, other ani¬ 
mals become easily carbunculous in their youth, and lose this 
faculty in adult life or when old ; such are the dog, horse and 
donkey, in which the young, subjects always succumb to inocula¬ 
tion, while later, a great many resist the disease. M. Chauveau 
has even demonstrated that in a breed of sheep from Algeria the 
greatest number resist bacteridian inoculation. 
These different observations suggested to me the idea of en¬ 
deavoring to place the organism in such a state that the bacteridie 
would be unable to find in it the necessary conditions of its devel¬ 
opment, and with this object in view I have undertaken many 
experiments. After numerous unsuccessful attempts, I at length 
arrived at a very simple method of preventing the bacteridie from ' 
multiplying in young dogs and in sheep. In other words, I am 
able actually to vaccinate sheep which resist inoculation and in- 
tra-vascular injections of considerable quantities of bacteridies, 
whether in the state of spores and obtained by culture, or in the 
form of short rods, as they are found in the blood of the animals 
which have recently died of the affection. The result of the ex¬ 
periments made up to the present time and which evidently de¬ 
monstrate this statement, I now present. 
Dogs. —I observed myself that dogs from birth to six months 
of age take anthrax very easily by simple punctures, and that 
when dead they present very large quantities of bacteridies in 
the blood, and at the same time very extensive local and glandular 
lesions. 
Eight hunting pups born of three dams were placed on experi¬ 
ment. Four were vaccinated by my process, and four were not. 
I had chosen my animals in such a way that in both lots there 
