HUMAN AND ANIMAL VARIOLAS. 
281 
HUMAN AND ANIMAL VARIOLAS: A STUDY IN COM¬ 
PARATIVE PATHOLOGY. 
By George Fleming, F.R.C.V.S., Army Veterinary Inspector. 
(From The Veterinary Journal, London, England. Reprinted from the Lancet for 
March 20 th.) 
(Continued from p. 246.) 
The apparent absence of a specific character in the papular 
eruption produced by inoculating the small-pox virus, might have 
led to the belief that it was merely inflammation produced at the 
seat of puncture. For instance, the first animal inoculated was a 
calf, which was inoculated at the vulva. A number of small 
papules appeared, and it was imagined that a very characteristic 
eruption of cow-pox was about to be developed; but instead of 
developing into pustules, they rapidly disappeared without leav¬ 
ing any trace of their existence, and then the result was consid¬ 
ered negative, and the animal put to one side. But being desirous, 
some time afterwards, of producing cow-pox by means of vaccine 
lymph of Neapolitan origin, this calf, being at hand, was vaccin¬ 
ated from a magnificent pustule raised on another calf which pre¬ 
sented a very fine vaccinal eruption. On the eighth day the 
inoculation had quite failed, greatly to the astonishment and re¬ 
gret of the Commission, as, relying on its success, they had not 
provided themselves with any more lymph, and had to send for 
another supply. Thinking that the inoculation had not been 
properly performed, when the new lymph came it was tried again 
with the utmost care, but another failure resulted in this calf, 
while with other two animals—a horse and a calf—vaccinated at 
the same time, there was a beautiful eruption. The Commission 
were now compelled to admit either that the small-pox inocula¬ 
tion had produced a specific eruption capable of protecting the 
animal from vaccinia, that it had been previously affected with 
that disease, or that it had no receptivity for the vaccine virus. 
At that time only about eight bovines had been vaccinated, and it 
was not certain whether this species would contract the cow-pox 
