HUMAN AND ANIMAL VARIOLAS. 
283 
To prove whether, after all. the papular eruption produced by 
small-pox might or might not be a mild kind of cow-pox, the 
feeble eruption of which could, by a methodical cultivation on 
bovines, become more developed, its transmission was attempted 
to other cows; for the eruption differed from human small-pox in 
being always local, while the papules, neither in volume, external 
characters, nor development, bore the slightest resemblance to 
that disease; whereas by its localization, development, and the 
absence of general phenomena, it did somewhat resemble cow- 
pox, though in other respects it widely differed. Three calves 
inoculated from the fully-developed eruption with all the care 
possible, showed still less local alteration, while with a young bull 
it entirely failed, and subsequent vaccination was most successful. 
From this it was concluded that the variolic virus, instead of 
being cultivable in the ox tribe, loses its activity, and scarcely 
produces any effect in the second generation. 
Was this eruption, then, merely that of modified small-pox? 
The results of small-pox inoculation on man are nearly as well 
known as natural small-pox itself, and there could be no mistake 
in the result if this bovine eruption was successfully re-trans- 
mitted to the human species. With the object of proving this, 
an unvaccinated infant, three months old, was inoculated with a 
very small quantity of serosity obtained by scraping some of the 
papules on a variolised cow. Four days afterwards on one of the 
punctures a pimple was noticed, which soon assumed all the char¬ 
acters of a vaccinal pustulla, and in nine days it was large, um- 
bilicated, surrounded by a red areoe ; very irregular at its periphery, 
and covered on its surface with a kind of small vesicle; it was 
aquarellee. When opened, only a very small quantity of fluid 
could be obtained from it to inoculate the arm of another child. 
Next day the infant was feverish and ill, and on examining it 
carefully a great number of small pimples were found on the 
face and trunk; on the following day these were fine variolic pus¬ 
tules, the majority of which were umbilicated, and formed a 
quasi-confluent eruption. In a week the pustules were desiccating 
and the child recovering. 
The child inoculated from this one had three punctures on 
