HUMAN AND ANIMAL VARIOLAS. 
323 
success of two or three persons in this direction many years ago. 
We may, if we choose, refer to the Lyons Commissioner’s experL 
ments and explanation for a reply, and conclude that the small¬ 
pox transferred to the cow remained small-pox still, though it was 
so modified in virulency, when re-transferred to man, as to pro¬ 
duce at first only a local eruption, though in some instances small¬ 
pox in a mild form followed. If I mistake not, more than one 
instance is on record, in which medical men have imitated Ceely 
and Badcock, and re-inoculating children from the cow, have pro¬ 
duced nothing but small-pox. Among other instances of this 
kind, I may refer to that of Martin (Boston Medical Journal , 
1860). That practitioner inoculated the udder of a cow with 
small-pox matter, and thought he had produced cow-pox. Col¬ 
lecting what he believed to be vaccine lymph from the vesicles, 
he vaccinated about fifty children with it, but produced only a 
serious outbreak of small-pox, from which several died. And a 
similar, but more alarming occurrence took place in India. Even 
in one of Ceely’s reported successful cases of vaccinia produced 
by variolation, we are informed that his assistant, in opening the 
supposed vaccine vesicle due to the small-pox virus, accidentally 
punctured his hand with the lancet, charged with moist lymph. 
On the fourth day there was a hard, deep-red, papular elevation 
at the seat of puncture. This was followed by constitutional dis 
turbance—as “ headache and other febrile symptoms, with roseola 
and fiery red papulae on the face and other parts.” On the sixth 
day the constitutional symptoms were more intense, and the papu¬ 
lae on the face, neck, trunk, and limbs exhibited ash-colored sum¬ 
mits on the seventh day, and the febrile symptoms were abated ; 
on the eighth day, the papulae were more yellow, and some were 
desiccating, but headache was still present. 
But if it is admitted that if it was really cow-pox Ceely and 
the animals were perfectly well. This cow, being in an advanced stage of the 
disease, and of course difficult to milk, was milked first in order by the juvenile 
milker, for three or four days only, when, becoming unmanageable by him, its 
former milker was called in to attend exclusively to it. In less than a week all 
the animals in this shed showed symptoms of the disease, though in a much 
milder degree than it had appeared in the other sheds, fewer manipulations hav¬ 
ing been performed by an infected hand. 
