362 
M. COLIN. 
EXPERIMENTAL ANALYSIS 
OF THE MALIGNANT PUSTULE AND CARBUNCU- 
LOUS (EDEMA; DETERMINATION OF THEIR 
VARIOUS FORMS AND OF THEIR 
DEGREES OF VIRULENCY.(*) 
By M. Colin, of Alfort. 
Continued from, page 264. 
II. 
I arrive at the second point of my communication, the most 
interesting. It covers several questions, first, the following: 
1st. Is the carbunculous pustule of the dog or that of other 
animals which have died from it, virulent ? 
2d. If it is, is it so at all its periods or at some determined 
time ? 
3d. If it is, how does its virulency stop spontaneously, without 
giving- rise to the general accidents which kill man and herbivo- 
rous animals ? 
Let us answer these questions : 
In the first place, one might believe, a prior'i , that the car¬ 
bunculous pustule, by the fact that it does not bring on general 
accidents on carnivora, is an incomplete pustule; pathologically 
considered a sterile and non-virulent pustule ? It is not so, how¬ 
ever. It is complete ; it is as fertile as in the species where it lias 
fatal terminations. 
But, to insure its virulency, one must proceed with method, 
not attack it too early and avoid to take up that which has been 
inserted in the puncture by the lancet or the needle. The liquid 
introduced in it preserving its properties for a certain time, would 
induce a belief in an artificial virulency. In 1873 I demon¬ 
strated that the septicemic virus, without action upon horse or 
donkey, is found intact after several days in the small puncture 
* From Archives Veterinaires. 
