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have recourse, it seems to ns, to certain experiments, similar to 
those which are now used for animals which are submitted to the 
preventive inoculation of anthrax, to find out if they have counter¬ 
acted immunity from that disease. It is known that this quality 
once obtained, the inoculation of carbunculous virus, known as 
very strong, gives rise only to slight phenomena, and even after 
two or three inoculations the organism becomes perfectly indiffer¬ 
ent to the insertion of new quantities of virus, even in large doses. 
Here is a way to follow to have the effects of pneumonic inocu¬ 
lation : Once done at the tail, the only region where it can be 
performed with impunity, on account of the intensity of the local 
phenomena following the insertion of the virus in parts where the 
connective tissue is loose and ready for rapid infiltration, another 
inoculation might be made, not at the tail, but upon another of these 
parts rich in cellular tissue, and allow to appreciate if the caudal in¬ 
oculation has really been successful in the sense of general infection. 
In fact, if it has had for result to protect the organism against the 
pleuro-pneumonic virus, as the preventive inoculation for anthrax, 
the insertion of that virus, no matter in what region, ought to be 
as harmless as that of carbunculous virus is, when immunity exists. 
If, on the contrary, this insertion gives rise on the cow inoculated 
at the tail, to phenomena as serious as those found in animals en¬ 
tirely virgin of all inoculation, proof will be evident that the virus 
inserted at the tail has been without general effect. This would 
be a criterion of a great certainty, which, in the case of positive 
solution, would allow no doubts upon the preventive effect of the 
caudal inoculation. I will add that once this question settled, it 
would become possible to take advantage of the obtained immunity 
by a first caudal inoculation in strengthening it by a second in 
another region ; the organism being sufficiently protected by the 
first, the other would be performed without danger in any region 
of the body .—Recueil de Medecine Veterinaire. 
