382 
GEORGE FLEMING. 
tingnish between the ordinary and the specitic malady. At last, 
lie states, he had the good fortune to find a horse on whose heels 
the matter was much more limpid than in all the preceding 
ones—on the fourteenth day of the disease, the seventh of the 
discharge from the heels. Four cows inoculated with this matter 
showed the usual symptoms of cow-pox, and a child also inoculated 
with it on the arm on the third day had a papule surrounded by 
slight inflammation ; on the fourth day the papule was very ele¬ 
vated, and on the fifth day there was a purple-tinted vesicle; on 
the sixth and seventh days the vesicle had increased and was 
darker. At the same time there was a fever, headache, quickened 
respiration, frequent pulse, white tongue, etc., which symptoms 
declined towards the ninth day. On the sixteenth day after in¬ 
oculation from the horse, the child was inoculated with small-pox 
matter without result. Loy alludes also to a farrier and a butcher 
of Pickering, who, in applying dressings to the heels of a horse 
affected with “ grease ” became inoculated. Desirous of ascer¬ 
taining whether the pustules which were on the hands and fore¬ 
head of the butcher could communicate the disease by inoculation, 
he inserted some of the matter from one of them into the arm of 
his brother, who had never had small-pox. The result was ex¬ 
actly the same as inoculating with cow-pox virus. Loy recognized 
two kinds of “grease”—one merely local and non-infective, the 
other local and constitutional (eruptive), which gives the disease 
to those who groom or handle the affected horses. With the first 
kind there was no general disturbance, but with the second at the 
commencement the horses exhibited symptoms of fever “ from 
which they were relieved as soon as the disease appeared at the 
heels, and there was an eruption of the skin. The horse, the 
matter from which communicated the disease by inoculation, was 
very unwell until the appearance of sore heels, which was, in all 
the other cases, accompanied by an eruption over the greater 
part of the body.” The fact that inoculation from the “ consti¬ 
tutional grease ” was a protection from small-pox, and that the 
rather severe effects of direct transmission from the horse to the 
human species were modified by passing the virus through the 
cow, or through mankind, was fully recognized by this enlightened 
