HUMAN AND ANIMAL VARIOLAS. 
387 
live days a purulent kind of discharge took place in the pastern, 
which continued for eight to ten days, during which the inflam¬ 
matory phenomena gradually subsided; then the pustules desic¬ 
cated, and towards the fifteenth day the crusts began to fall off, 
carrying the tufts of hair with them, and leaving more or less per¬ 
ceptible cicatrices. The eruption appeared not only on the limbs, 
but on other parts of the body, particularly on the nostrils, lips, 
flanks and vulva. There was no cow-pox present in the locality, 
and the extension of the disease seemed to be due entirely to con¬ 
tagion. No fewer than eighty mares were infected from being 
sent to the government stallions at Rieumes, the ropes with which 
their hind limbs were secured (passing round the pastern) being 
impregnated with the discharge from the heels of some diseased 
mare. Only three mares and two stallions escaped attack. One 
of the animals exposed to infection chanced to be sent to Toulouse, 
and not appearing so well as usual, it was left at the government 
veterinary school. It was not until it had been there for eight 
days that Professor Lafosse observed the mare to be dull, suffering 
from inappetence, and lameness in both hind limbs, with difficulty 
in flexing the fetlocks, and a hot, painful swelling, confined to the 
left fetlock, extending higher on the right leg. On these swollen 
parts small tufts of hair were erect here and there, and at those 
places there were what appeared to be pustules, from which exu¬ 
ded a fluid matter possessed of ammoniacal odor, but less fetid 
than that of stearrhcea (“ grease ”). Lafosse thought at first that 
it was only the latter disease in an acute form ; and he was hap¬ 
pily inspired to inoculate a cow. in order, once more, to submit 
the Jenncrian doctrine to an experimental test. The experiment 
was made eight days after the manifestation of the eruption on 
the mare, and was perfectly successful. Papules, then pustules, 
formed on the cow wherever the matter obtained from the mare 
had been inserted with the lancet—large, flat, firm and round pus¬ 
tules, with a central umbilicus, which caused the borders to ap¬ 
pear raised—they were the vaccine vesicles, in fact. Another 
cow was inoculated from this one, and had a very fine cow-pox, 
from which a child and a horse were vaccinated, and these had a 
magnificent vaccinal eruption. A second child, inoculated with 
