GEORGE FLEMING. 
388 
the matter from this horse, had, in its turn, a well-developed pock. 
Comparative inoculations were then made on children and horses 
with the equine virus and the ordinary humanized vaccine, and it 
was found that the former produced larger and finer pustules than 
the latter, though their evolution was slower. Lafosse designated 
the disease the maladiepustuluse vaccinogene of the horse. 
Bouley, then professor of clinics at the Alfort veterinary 
school, not quite satisfied with what had been done in this direc¬ 
tion by Lafosse and others, resolved to inoculate cows witli all 
the eruptive maladies of the horse, which his daily routine of pro¬ 
fessional duty brought before him ; and, singular to relate, the 
very first case (in 1863), was a successful one, and produced a 
beautiful cow-pox. The horse presented the following symptoms : 
On the inner surface of the lips, on the inferior aspect and free 
portion of the tongue, on the buccal and gingival membrane and 
on the floor of the mouth—particularly along the Wbartonian 
ducts—were infinite multitudes of small vesicles, about the size of 
a pea, some circular, others elongated, and whose opaline tint was 
in marked contrast to the briorht-red mucous membrane on which 
<TJ 
they were seated. These pearl-tinted vesicles were smooth on their 
surface, had no depression, and felt rather tense; pain was evinced 
when they were pressed upon. In some places they were confluent, 
in others discrete. When they had been ruptured, there were 
small, lenticular, very red sores, with sharply defined borders. A 
very abundant saliva, rendered frothy by the incessant movement 
of the tongue, filled the mouth, and escaped in long masses from 
its commissures. With the exception of not eating so well as 
usual, the horse appeared in good health. The symptoms were so 
different from those described by Loy and Lafosse, that Bouley 
thought it was an apthous stomatitis, and that therefore, like the 
foot-and-mouth disease of bovines, it must be contagious. True 
to his resolve,, he inoculated a cow to see what the result would 
be, and produced veritable cow-pox, from which children were 
most successfully vaccinated. For some months other horses were 
admitted to the clinic of the school, suffering fr nn the same dis¬ 
ease, which varied in its symptoms only with regard to the seat of 
eruption, which was in some instances as in the first ease, and in 
