420 
I)R. WILLEMS. 
constipation and then foetid diarrhoea, sometimes convulsive 
motions of the head and body, grinding of the teeth, &c. 
In the affected tissues, one finds infiltration of a matter of 
exudation which fills up the connective tissue, either ordinarily in 
the lungs, when the disease is taken by contagion, or upon the 
point where inoculation lias been made. Infiltrations of serous 
licpiid are often seen when pleuro-pneumonia is in an advanced 
stage, as also after inoculation, in the pleura, pericardium, peri¬ 
toneum, cellular tissue surrounding the trachea, in the liver, the 
muscles, etc. 
When the disease is far advanced, it affects almost all the 
organs, as proved to me by the numerous autopsies I have made ; 
even muscles are impregnated with a gelatinous exudation. 
This plastic exudation may be carried anywhere else than the 
lungs; it is not even absolutely necessary to the existence of that 
affection. I have met animals affected with exudative pleuro¬ 
pneumonia without pulmonary lesions; the liver presents some¬ 
times a plastic infiltration analogous to that of the lung. It is a 
fact of observation, noted by several experimentors, amongst 
which are M.M. Delafond, Zundel, and EL Bouley. The latter says •’ 
“ The virus of peripneumonia can saturate an organism and pro¬ 
tect it from further attacks of this disease, without, however, mani¬ 
festing its presence by the inflammatory disease of the lungs and 
the plastic transudations belonging to it.” 
The autopsy of animals which have died from inoculation 
show the same cadaveric lesions as are found in those which have 
succumbed to the disease. 
“ What veterinary surgeons inoculate,” says M. Paul Cagny, 
a young and learned veterinarian, “is peripneumonia with all its 
virulency; the local symptoms only differ from the disease inoc¬ 
ulated naturally, or those from that introduced by the lancet. 
This is due to the anatomical organization first, and again to the 
physiological action of the organs at the point of inoculation. It 
is for that reason that inoculation on the dew-lap had to be aban¬ 
doned.” 
These very great alterations cannot be explained but by a 
deep modification in the constituting elements of the blood which 
